Our Scientific Publications & Presentations

TITLE

APL-2 Prevents Both C3 and C5 Convertase Formation and Activity: A Potential Therapeutic for Renal Diseases

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SPEAKER/AUTHOR

Veronique Fremeaux-Bacchi

CONFERENCE/JOURNAL

American Society of Nephrology (ASN)

DATE

11/09/19


TITLE

C3 Inhibition With APL-2 Targets the Underlying Disease Process of C3G Complement Hyperactivity and Improves Proteinuria

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SPEAKER/AUTHOR

Bradley P. Dixon

CONFERENCE/JOURNAL

American Society of Nephrology (ASN)

DATE

11/07/19


Title

Inhibiting Complement C3 with APL-2 Controls Haemolysis and Increases Haemoglobin Levels in Patients With Autoimmune Haemolytic Anemia (AIHA)

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Speaker/
Author

Bruno Fattizzo

Conference/
Journal

European Hematology Association (EHA)

Date

06/15/19


Title

Evaluation of Baseline Risk Factors on Progression in Geographic Atrophy: Post-hoc Analysis from the FILLY Study

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Speaker/
Author

Nathan Steinle

Conference/
Journal

Association for Research in Vision and Ophthalmology (ARVO)

Date

04/28/19


Title

Inhibiting Complement C3 With APL-2 Controls Haemolysis and Increases Hemoglobin Levels in Patients With Autoimmune Hemolytic Anemia (AIHA)

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Speaker/
Author

Bruno Fattizzo

Conference/
Journal

British Society of Haematology

Date

04/02/19


Title

Inhibition of C3 with APL-2 Results in Normalisation of Markers of Intravascular and Extravascular Haemolysis in Patients with Paroxysmal Nocturnal Haemoglobinuria

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Speaker/
Author

Raymond Wong

Conference/
Journal

British Society of Haematology

Date

04/01/19


Title

Poster: Inhibition of C3 With APL-2 Results in Normalization of Markers of Intravascular and Extravascular Hemolysis in Subjects with Paroxysmal Nocturnal Hemoglobinuria (PNH)

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Speaker/
Author

Raymond Wong

Conference/
Journal

American Society of Hematology (ASH)

Date

12/02/18


Title

Poster: Inhibition of C3 With APL-2 Controls Hemolysis and Increases Hemoglobin Levels in Subjects With Autoimmune Hemolytic Anemia (AIHA)

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Speaker/
Author

Morie Gertz

Conference/
Journal

ASH

Date

12/02/18


Title

Poster: Treatment With APL-2 in Patients Who Remain Anemic Despite Treatment With Soliris® Leads to Increases in Hemoglobin, Transfusion Avoidance and Broad Control of Hemolysis

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Speaker/
Author

Carlos De Castro

Conference/
Journal

Congresso Brasileiro de Hematologia, Hemoterapia e Terapia Celular (HEMO)

Date

10/31/18


Title

Presentation: Complement C3 Inhibition in Geographic Atrophy

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Speaker/
Author

Jason Slakter

Conference/
Journal

EURETINA

Date

09/22/18


Title

Presentation: APL-2, a Complement C3 Inhibitor, Slows the Growth of Geographic Atrophy Secondary to AMD: 18-Month Results

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Speaker/
Author

David Brown

Conference/
Journal

Retina Society

Date

09/13/18


Title

Poster: APL-2, A Complement C3 Inhibitor, Slows the Growth of Geographic Atrophy Secondary to AMD: 18-Month Results of a Phase 2 Trial (FILLY).

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Speaker/
Author

Charles Wykoff

Conference/
Journal

The Association for Research in Vision and Ophthalmology (ARVO)

Date

04/30/18


Title

Poster: APL-2, a Complement C3 Inhibitor, May Potentially Reduce Both Intravascular and Extravascular Hemolysis in Patients With Paroxysmal Nocturnal Hemoglobinuria

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Speaker/
Author

Delphine El Mehdi

Conference/
Journal

European Meeting on Complement in Human Disease (EMCHD)

Date

09/11/17


Title

Abstract: Repeat Measurements of Complement Proteins C3a and C5a in COPD Patients

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Speaker/
Author

Thomas Southworth

Conference/
Journal

European Respiratory Society

Date

09/10/17


Title

Poster: Prediction of Duration of C3 Inhibition With APL‐2 in Human Eyes Using a PK/PD Binding Model

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Speaker/
Author

Pascal Deschatelets

Conference/
Journal

ARVO

Date

05/07/17


Title

Poster: APL-2, a Complement C3 Inhibitor for the Potential Treatment of Paroxysmal Nocturnal Hemoglobinuria (PNH): Phase I Data from Two Completed Studies in Healthy Volunteers

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Speaker/
Author

Federico Grossi

Conference/
Journal

American Society of Hematology (ASH)

Date

12/03/16


Title

Presentation: APL-2 and Complement Inhibition; a Potential Treatment of PNH and Other Complement-Mediated Diseases

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Speaker/
Author

Caroline Vega

Conference/
Journal

Boulder Peptide Symposium

Date

09/27/16


Title

Presentation: Complement Immunotherapy Using Compstatin Derivatives

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Speaker/
Author

Delphine El Mehdi

Conference/
Journal

Aegean Complement Theraputics

Date

06/29/16


Title

Presentation: Complement C3 Inhibition in AMD

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Speaker/
Author

Cedric Francois

Conference/
Journal

Angiogenesis

Date

02/06/16


Title

Publication: Small Peptides for Inhibition of Central Component of Immunity: the Complement System

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Speaker/
Author

Delphine El Mehdi & Pascal Deschatelets

Conference/
Journal

Chemistry Today

Date

3/2016


Title

Poster: Ocular Coherence Tomography Supports an Investigational New Drug Application for a C3 Complement Inhibitor Targeting Macular Degeneration

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Speaker/
Author

Margaret Collins

Conference/
Journal

Society Of Toxicology (SOT)

Date

03/23/15


Title

Publication: Complement Immunotherapy: Therapeutic Thought

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Speaker/
Author

Cedric Francois & Pascal Deschatelets

Conference/
Journal

European Pharmaceutical Contractor

Date

03/2015


Title

Poster: Red Cell Complement Loading in PNH Patients on Eculizumab is Associated With a C3 Polymorphism Which Influences C3 Function, Predicts for Increased Extravascular Haemolysis and Provides a Rationale for C3 Inhibition

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Speaker/
Author

Praveen Kaudlay

Conference/
Journal

ASH

Date

12/08/13