Clinical Trials

Leaders in targeted C3 therapies, we aim to develop transformative therapies for a broad range of debilitating diseases that are driven by excessive activation of the complement cascade, including those within hematology, ophthalmology, nephrology, and neurology.

Visit clinicaltrials.gov to learn more about study participation including eligibility, risks and benefits participation, the informed consent process, questions to ask when considering study participation.

If you have questions about our clinical trials, please email us at clinicaltrials@apellis.com. Learn more about ongoing, Apellis-sponsored clinical trials below.

Paroxysmal Nocturnal Hemoglobinuria (PNH)

ACTIVE, NOT RECRUITING

PEGASUS: A Phase 3 study to evaluate the efficacy and safety of pegcetacoplan (APL‑2) in patients with paroxysmal nocturnal hemoglobinuria

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clinicaltrials.gov

ACTIVE, NOT RECRUITING

PRINCE: A Phase 3, randomized, multicenter, open-label, controlled study to evaluate the efficacy and safety of pegcetacoplan (APL‑2) in patients with PNH

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clinicaltrials.gov

COMPLETED

PADDOCK: Pilot study to assess safety, preliminary efficacy and pharmacokinetics of subcutaneous pegcetacoplan (APL‑2) in patients with PNH

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clinicaltrials.gov

ACTIVE, NOT RECRUITING

PALOMINO: A Phase 2a, open-label study to evaluate the efficacy and safety of pegcetacoplan (APL‑2) in patients with PNH who have never been treated with eculizumab

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clinicaltrials.gov

COMPLETED

PHAROAH: A Phase 1 study to assess the safety of pegcetacoplan (APL‑2) as an add-on to standard of care in patients with PNH

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clinicaltrials.gov

ENROLLING BY INVITATION

An open-label, nonrandomized, multicenter extension study to evaluate the long term safety and efficacy of pegcetacoplan (APL‑2) in patients with PNH

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clinicaltrials.gov


Geographic Atrophy (GA)

ACTIVE, NOT RECRUITING

DERBY: A Phase 3 study to evaluate the efficacy and safety of pegcetacoplan (APL-2) in patients with GA secondary to age-related macular degeneration

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clinicaltrials.gov

ACTIVE, NOT RECRUITING

OAKS: A Phase 3 study to evaluate the efficacy and safety of pegcetacoplan (APL-2) in patients with GA secondary to age-related macular degeneration

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clinicaltrials.gov


Amyotrophic Lateral Sclerosis (ALS)

ACTIVE, RECRUITING

MERIDIAN: A Phase 2 study evaluating the efficacy and safety of pegcetacoplan in patients with sporadic ALS

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clinicaltrials.gov


Nephropathies – C3G / IC-MPGN

ACTIVE, RECRUITING

NOBLE: A Phase 2 study evaluating the safety and efficacy of pegcetacoplan in the treatment of post-transplant recurrence C3G or IC-MPGN

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clinicaltrials.gov

ACTIVE, NOT RECRUITING

DISCOVERY: Phase 2 study assessing safety and efficacy of pegcetacoplan (APL‑2) in glomerulopathies

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clinicaltrials.gov


Autoimmune Hemolytic Anemia (AIHA)

ACTIVE, NOT RECRUITING

PLAUDIT: A Phase 2, prospective, open-label study to assess the safety, tolerability, preliminary efficacy, pharmacokinetics and pharmacodynamics of multiple doses of pegcetacoplan (APL‑2) in patients with autoimmune hemolytic anemia (AIHA).

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clinicaltrials.gov


COVID-19

ACTIVE, RECRUITING

COV-201: A Phase 1/2 study evaluating the safety and efficacy of APL-9 in adults with mild to moderate acute respiratory distress syndrome (ARDS) due to COVID-19

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clinicaltrials.gov