Clinical Trials

By pioneering targeted C3 therapies, we aim to develop best-in-class and first-in-class therapies for a broad range of debilitating diseases that are driven by uncontrolled or excessive activation of the complement cascade, including those within hematology, ophthalmology, and nephrology.

Visit clinicaltrials.gov to learn more about study participation including eligibility, risks and benefits participation, the informed consent process, questions to ask when considering study participation.

If you have questions about our clinical trials, please email us at clinicaltrials@apellis.com. Learn more about ongoing, Apellis-sponsored clinical trials below.

Paroxysmal Nocturnal Hemoglobinuria (PNH)

ACTIVE, NOT RECRUITING

PEGASUS: A Phase 3 study to evaluate the efficacy and safety of pegcetacoplan (APL‑2) in patients with paroxysmal nocturnal hemoglobinuria

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clinicaltrials.gov

ACTIVE, NOT RECRUITING

PRINCE: A Phase 3, randomized, multicenter, open-label, controlled study to evaluate the efficacy and safety of pegcetacoplan (APL‑2) in patients with PNH

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clinicaltrials.gov

COMPLETED

PADDOCK: Pilot study to assess safety, preliminary efficacy and pharmacokinetics of subcutaneous pegcetacoplan (APL‑2) in patients with PNH

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clinicaltrials.gov

ACTIVE, NOT RECRUITING

PALOMINO: A Phase 2a, open-label study to evaluate the efficacy and safety of pegcetacoplan (APL‑2) in patients with PNH who have never been treated with eculizumab

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clinicaltrials.gov

COMPLETED

PHAROAH: A Phase 1 study to assess the safety of pegcetacoplan (APL‑2) as an add-on to standard of care in patients with PNH

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clinicaltrials.gov

ENROLLING BY INVITATION

An open-label, nonrandomized, multicenter extension study to evaluate the long term safety and efficacy of pegcetacoplan (APL‑2) in patients with PNH

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clinicaltrials.gov

Geographic Atrophy (GA)

ACTIVE, NOT RECRUITING

DERBY: A Phase 3 study to evaluate the efficacy and safety of pegcetacoplan (APL-2) in patients with GA secondary to age-related macular degeneration

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clinicaltrials.gov

ACTIVE, NOT RECRUITING

OAKS: A Phase 3 study to evaluate the efficacy and safety of pegcetacoplan (APL-2) in patients with GA secondary to age-related macular degeneration

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clinicaltrials.gov

Autoimmune Hemolytic Anemia (AIHA)

ACTIVE, NOT RECRUITING

PLAUDIT: A Phase 2, prospective, open-label study to assess the safety, tolerability, preliminary efficacy, pharmacokinetics and pharmacodynamics of multiple doses of pegcetacoplan (APL‑2) in patients with autoimmune hemolytic anemia (AIHA).

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clinicaltrials.gov

Nephropathies

ACTIVE, NOT RECRUITING

DISCOVERY: Phase 2 study assessing safety and efficacy of pegcetacoplan (APL‑2) in glomerulopathies

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clinicaltrials.gov