Who We Are

At Apellis, we combine courageous science and compassion to develop life-changing medicines for some of the most challenging diseases patients face.

Leading the way in complement science

Our goal is to transform treatment for a broad range of debilitating diseases by controlling a part of the immune system known as the complement cascade, which can damage healthy cells and tissues when overactivated.

In 2021, we ushered in the first new class of complement medicine in 15 years. We now have two first-in-class medicines targeting C3 across four diseases. C3 is the central protein in the complement cascade and the only target that addresses all three pathways that can initiate and drive disease.

Transforming patient care

We are delivering meaningful advances for patients with serious diseases who previously had few, or no, approved treatment options. Our medicines are making a difference for patients with:

  • Geographic atrophy (GA) – a leading cause of blindness
  • C3 glomerulopathy (C3G) and primary immune complex-mediated membranoproliferative glomerulonephritis (IC-MPGN) –  two severe, rare kidney diseases
  • Paroxysmal nocturnal hemoglobinuria (PNH) – a rare, life-threatening blood disorder.

And we believe we have only begun to unlock the full potential of targeting C3 for patients.

We replace impossible with how  

More than a decade ago in a university lab in Kentucky, a small group of post-doc scientists, including our Chief Executive Officer and Chief Scientific Officer, started a biotech company with a scientific approach that challenged conventional thinking.

At the time, targeting C3 was viewed as scientifically difficult, if not impossible by many, but the significant unmet needs of patients inspired our founders’ efforts to follow the science and continue to drive us forward today.

With perseverance and passion, we have advanced two C3-targeting medicines from discovery through development and commercialization. Today, we are leveraging our complement expertise to develop new treatments for patients living with serious diseases.

We Are Apellis

Apellis is formed by people who care, who are fearless in the face of a challenge, who love the work they do, and who continually pursue the highest level of scientific integrity. Each of these values guides every decision we make as we strive toward our vision of being known for our compassion, revolutionary science, and contributions to humankind around the world.

OUR CULTURE

Our Responsibility

We care fiercely about the greater good of society and believe corporate responsibility is foundational to achieving our vision.

We strive to bring transformative medicines to patients, to provide an engaging and inclusive workplace for our employees, to minimize our impact on the environment, and always to demonstrate integrity in our actions.

We are committed to becoming a sustainable company that delivers on its promise to patients, communities, and the world.

“When we started this company, we agreed that we’re going to do well by doing good. If we were to fail by doing the right thing there would be no regret.”

Pascal Deschatelets, PhD
Co-Founder & Chief Scientific Officer